                         SEQUENCE LISTING

<110>  COLUMBIA UNIVERISTY/ RAMON PARSONS
 
<120>  IDENTIFICATION OF EXTRACELLULAR FORM OF PTEN THAT CAN BE USED TO 
       TREAT TUMORS

<130>  0575/79943-A-PCT/JPW/BJA

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  576
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(173)
<223>  PTEN-long specific protein sequence encoded by 5' ATR starting at
       CUG start codon

<220>
<221>  MISC_FEATURE
<222>  (174)..(174)
<223>  Initiator Met of PTEN

<400>  1

Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 
                165                 170                 175     


Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 
            180                 185                 190         


Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met 
        195                 200                 205             


Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn Asn Ile Asp 
    210                 215                 220                 


Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His Tyr Lys Ile 
225                 230                 235                 240 


Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys Phe Asn Cys 
                245                 250                 255     


Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro Gln Leu Glu 
            260                 265                 270         


Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu Ser Glu Asp 
        275                 280                 285             


Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys Gly Arg Thr 
    290                 295                 300                 


Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys Phe Leu Lys 
305                 310                 315                 320 


Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr Arg Asp Lys 
                325                 330                 335     


Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr Tyr Tyr Ser 
            340                 345                 350         


Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala Leu Leu Phe 
        355                 360                 365             


His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly Gly Thr Cys 
    370                 375                 380                 


Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile Tyr Ser Ser 
385                 390                 395                 400 


Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr Phe Glu Phe 
                405                 410                 415     


Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu Phe Phe His 
            420                 425                 430         


Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His Phe Trp Val 
        435                 440                 445             


Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu Lys Val Glu 
    450                 455                 460                 


Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 
465                 470                 475                 480 


Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu Thr Lys Asn 
                485                 490                 495     


Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr Phe Ser Pro 
            500                 505                 510         


Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
        515                 520                 525             


Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp Val Ser Asp 
    530                 535                 540                 


Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp Ser Asp Pro 
545                 550                 555                 560 


Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile Thr Lys Val 
                565                 570                 575     


<210>  2
<211>  5572
<212>  RNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (513)..(515)
<223>  CUG initiation codon of PTEN-long

<220>
<221>  misc_feature
<222>  (513)..(1031)
<223>  5' ATR of PTEN-long

<220>
<221>  misc_feature
<222>  (1032)..(1034)
<223>  Canonical AUG initiation codon of PTEN

<400>  2
ccuccccucg cccggcgcgg ucccguccgc cucucgcucg ccucccgccu ccccucgguc       60

uuccgaggcg cccgggcucc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggu      120

gauguggcgg gacucuuuau gcgcugcggc aggauacgcg cucggcgcug ggacgcgacu      180

gcgcucaguu cucuccucuc ggaagcugca gccaugaugg aaguuugaga guugagccgc      240

ugugaggcga ggccgggcuc aggcgaggga gaugagagac ggcggcggcc gcggcccgga      300

gccccucuca gcgccuguga gcagccgcgg gggcagcgcc cucggggagc cggccggccu      360

gcggcggcgg cagcggcggc guuucucgcc uccucuucgu cuuuucuaac cgugcagccu      420

cuuccucggc uucuccugaa agggaaggug gaagccgugg gcucgggcgg gagccggcug      480

aggcgcggcg gcggcggcgg caccucccgc uccuggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggcugca gcuccaggga gggggucuga gucgccuguc accauuucca      600

gggcugggaa cgccggagag uuggucucuc cccuucuacu gccuccaaca cggcggcggc      660

ggcggcggca cauccaggga cccgggccgg uuuuaaaccu cccguccgcc gccgccgcac      720

cccccguggc ccgggcuccg gaggccgccg gcggaggcag ccguucggag gauuauucgu      780

cuucucccca uuccgcugcc gccgcugcca ggccucuggc ugcugaggag aagcaggccc      840

agucgcugca accauccagc agccgccgca gcagccauua cccggcugcg guccagagcc      900

aagcggcggc agagcgaggg gcaucagcua ccgccaaguc cagagccauu uccauccugc      960

agaagaagcc ccgccaccag cagcuucugc caucucucuc cuccuuuuuc uucagccaca     1020

ggcucccaga caugacagcc aucaucaaag agaucguuag cagaaacaaa aggagauauc     1080

aagaggaugg auucgacuua gacuugaccu auauuuaucc aaacauuauu gcuaugggau     1140

uuccugcaga aagacuugaa ggcguauaca ggaacaauau ugaugaugua guaagguuuu     1200

uggauucaaa gcauaaaaac cauuacaaga uauacaaucu uugugcugaa agacauuaug     1260

acaccgccaa auuuaauugc agaguugcac aauauccuuu ugaagaccau aacccaccac     1320

agcuagaacu uaucaaaccc uuuugugaag aucuugacca auggcuaagu gaagaugaca     1380

aucauguugc agcaauucac uguaaagcug gaaagggacg aacuggugua augauaugug     1440

cauauuuauu acaucggggc aaauuuuuaa aggcacaaga ggcccuagau uucuaugggg     1500

aaguaaggac cagagacaaa aagggaguaa cuauucccag ucagaggcgc uauguguauu     1560

auuauagcua ccuguuaaag aaucaucugg auuauagacc aguggcacug uuguuucaca     1620

agaugauguu ugaaacuauu ccaauguuca guggcggaac uugcaauccu caguuugugg     1680

ucugccagcu aaaggugaag auauauuccu ccaauucagg acccacacga cgggaagaca     1740

aguucaugua cuuugaguuc ccucagccgu uaccugugug uggugauauc aaaguagagu     1800

ucuuccacaa acagaacaag augcuaaaaa aggacaaaau guuucacuuu uggguaaaua     1860

cauucuucau accaggacca gaggaaaccu cagaaaaagu agaaaaugga agucuaugug     1920

aucaagaaau cgauagcauu ugcaguauag agcgugcaga uaaugacaag gaauaucuag     1980

uacuuacuuu aacaaaaaau gaucuugaca aagcaaauaa agacaaagcc aaccgauacu     2040

uuucuccaaa uuuuaaggug aagcuguacu ucacaaaaac aguagaggag ccgucaaauc     2100

cagaggcuag caguucaacu ucuguaacac cagauguuag ugacaaugaa ccugaucauu     2160

auagauauuc ugacaccacu gacucugauc cagagaauga accuuuugau gaagaucagc     2220

auacacaaau uacaaaaguc ugaauuuuuu uuuaucaaga gggauaaaac accaugaaaa     2280

uaaacuugaa uaaacugaaa auggaccuuu uuuuuuuuaa uggcaauagg acauuguguc     2340

agauuaccag uuauaggaac aauucucuuu uccugaccaa ucuuguuuua cccuauacau     2400

ccacaggguu uugacacuug uuguccaguu gaaaaaaggu uguguagcug ugucauguau     2460

auaccuuuuu gugucaaaag gacauuuaaa auucaauuag gauuaauaaa gauggcacuu     2520

ucccguuuua uuccaguuuu auaaaaagug gagacagacu gauguguaua cguaggaauu     2580

uuuuccuuuu guguucuguc accaacugaa guggcuaaag agcuuuguga uauacugguu     2640

cacauccuac cccuuugcac uuguggcaac agauaaguuu gcaguuggcu aagagagguu     2700

uccgaagggu uuugcuacau ucuaaugcau guauucgggu uaggggaaug gagggaaugc     2760

ucagaaagga aauaauuuua ugcuggacuc uggaccauau accaucucca gcuauuuaca     2820

cacaccuuuc uuuagcaugc uacaguuauu aaucuggaca uucgaggaau uggccgcugu     2880

cacugcuugu uguuugcgca uuuuuuuuua aagcauauug gugcuagaaa aggcagcuaa     2940

aggaagugaa ucuguauugg gguacaggaa ugaaccuucu gcaacaucuu aagauccaca     3000

aaugaaggga uauaaaaaua augucauagg uaagaaacac agcaacaaug acuuaaccau     3060

auaaaugugg aggcuaucaa caaagaaugg gcuugaaaca uuauaaaaau ugacaaugau     3120

uuauuaaaua uguuuucuca auuguaacga cuucuccauc uccuguguaa ucaaggccag     3180

ugcuaaaauu cagaugcugu uaguaccuac aucagucaac aacuuacacu uauuuuacua     3240

guuuucaauc auaauaccug cuguggaugc uucaugugcu gccugcaagc uucuuuuuuc     3300

ucauuaaaua uaaaauauuu uguaaugcug cacagaaauu uucaauuuga gauucuacag     3360

uaagcguuuu uuuucuuuga agauuuauga ugcacuuauu caauagcugu cagccguucc     3420

acccuuuuga ccuuacacau ucuauuacaa ugaauuuugc aguuuugcac auuuuuuaaa     3480

ugucauuaac uguuagggaa uuuuacuuga auacugaaua cauauaaugu uuauauuaaa     3540

aaggacauuu guguuaaaaa ggaaauuaga guugcaguaa acuuucaaug cugcacacaa     3600

aaaaaagaca uuugauuuuu caguagaaau uguccuacau gugcuuuauu gauuugcuau     3660

ugaaagaaua ggguuuuuuu uuuuuuuuuu uuuuuuuuuu uuaaaugugc aguguugaau     3720

cauuucuuca uagugcuccc ccgaguuggg acuagggcuu caauuucacu ucuuaaaaaa     3780

aaucaucaua uauuugauau gcccagacug cauacgauuu uaagcggagu acaacuacua     3840

uuguaaagcu aaugugaaga uauuauuaaa aagguuuuuu uuuccagaaa uuuggugucu     3900

ucaaauuaua ccuucaccuu gacauuugaa uauccagcca uuuuguuucu uaaugguaua     3960

aaauuccauu uucaauaacu uauuggugcu gaaauuguuc acuagcugug gucugaccua     4020

guuaauuuac aaauacagau ugaauaggac cuacuagagc agcauuuaua gaguuugaug     4080

gcaaauagau uaggcagaac uucaucuaaa auauucuuag uaaauaaugu ugacacguuu     4140

uccauaccuu gucaguuuca uucaacaauu uuuaaauuuu uaacaaagcu cuuaggauuu     4200

acacauuuau auuuaaacau ugauauauag aguauugauu gauugcucau aaguuaaauu     4260

gguaaaguua gagacaacua uucuaacacc ucaccauuga aauuuauaug ccaccuuguc     4320

uuucauaaaa gcugaaaauu guuaccuaaa augaaaauca acuucauguu uugaagauag     4380

uuauaaauau uguucuuugu uacaauuucg ggcaccgcau auuaaaacgu aacuuuauug     4440

uuccaauaug uaacauggag ggccagguca uaaauaauga cauuauaaug ggcuuuugca     4500

cuguuauuau uuuuccuuug gaaugugaag gucugaauga ggguuuugau uuugaauguu     4560

ucaauguuuu ugagaagccu ugcuuacauu uuauggugua gucauuggaa auggaaaaau     4620

ggcauuauau auauuauaua uauaaauaua uauuauacau acucuccuua cuuuauuuca     4680

guuaccaucc ccauagaauu ugacaagaau ugcuaugacu gaaagguuuu cgaguccuaa     4740

uuaaaacuuu auuuauggca guauucauaa uuagccugaa augcauucug uagguaaucu     4800

cugaguuucu ggaauauuuu cuuagacuuu uuggaugugc agcagcuuac augucugaag     4860

uuacuugaag gcaucacuuu uaagaaagcu uacaguuggg cccuguacca ucccaagucc     4920

uuuguagcuc cucuugaaca uguuugccau acuuuuaaaa ggguaguuga auaaauagca     4980

ucaccauucu uugcuguggc acagguuaua aacuuaagug gaguuuaccg gcagcaucaa     5040

auguuucagc uuuaaaaaau aaaaguaggg uacaaguuua auguuuaguu cuagaaauuu     5100

ugugcaauau guucauaacg auggcugugg uugccacaaa gugccucguu uaccuuuaaa     5160

uacuguuaau gugucaugca ugcagaugga agggguggaa cugugcacua aagugggggc     5220

uuuaacugua guauuuggca gaguugccuu cuaccugcca guucaaaagu ucaaccuguu     5280

uucauauaga auauauauac uaaaaaauuu cagucuguua aacagccuua cucugauuca     5340

gccucuucag auacucuugu gcugugcagc aguggcucug uguguaaaug cuaugcacug     5400

aggauacaca aaaauaccaa uaugaugugu acaggauaau gccucauccc aaucagaugu     5460

ccauuuguua uuguguuugu uaacaacccu uuaucucuua guguuauaaa cuccacuuaa     5520

aacugauuaa agucucauuc uugucaaaaa aaaaaaaaaa aaaaaaaaaa aa             5572


<210>  3
<211>  5572
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (513)..(515)
<223>  CTG initiation codon of PTEN-long

<220>
<221>  misc_feature
<222>  (513)..(1031)
<223>  5' ATR of PTEN-long

<220>
<221>  misc_feature
<222>  (1032)..(1034)
<223>  Canonical ATG initiation codon of PTEN

<400>  3
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aa             5572


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser Phe Phe Phe Ser 
1               5                   10                  15      


His Arg Leu Pro Asp 
            20      


<210>  5
<211>  576
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(173)
<223>  PTEN-long analogue protein sequence encoded by 5' ATR starting at
       engineered AUG start codon

<400>  5

Met Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 
                165                 170                 175     


Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 
            180                 185                 190         


Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met 
        195                 200                 205             


Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn Asn Ile Asp 
    210                 215                 220                 


Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His Tyr Lys Ile 
225                 230                 235                 240 


Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys Phe Asn Cys 
                245                 250                 255     


Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro Gln Leu Glu 
            260                 265                 270         


Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu Ser Glu Asp 
        275                 280                 285             


Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys Gly Arg Thr 
    290                 295                 300                 


Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys Phe Leu Lys 
305                 310                 315                 320 


Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr Arg Asp Lys 
                325                 330                 335     


Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr Tyr Tyr Ser 
            340                 345                 350         


Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala Leu Leu Phe 
        355                 360                 365             


His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly Gly Thr Cys 
    370                 375                 380                 


Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile Tyr Ser Ser 
385                 390                 395                 400 


Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr Phe Glu Phe 
                405                 410                 415     


Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu Phe Phe His 
            420                 425                 430         


Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His Phe Trp Val 
        435                 440                 445             


Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu Lys Val Glu 
    450                 455                 460                 


Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 
465                 470                 475                 480 


Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu Thr Lys Asn 
                485                 490                 495     


Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr Phe Ser Pro 
            500                 505                 510         


Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
        515                 520                 525             


Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp Val Ser Asp 
    530                 535                 540                 


Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp Ser Asp Pro 
545                 550                 555                 560 


Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile Thr Lys Val 
                565                 570                 575 

<210>  6
<211>  5572
<212>  RNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (513)..(515)
<223>  Engineered AUG initiation codon of PTEN-long analogue

<400>  6
ccuccccucg cccggcgcgg ucccguccgc cucucgcucg ccucccgccu ccccucgguc       60

uuccgaggcg cccgggcucc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggu      120

gauguggcgg gacucuuuau gcgcugcggc aggauacgcg cucggcgcug ggacgcgacu      180

gcgcucaguu cucuccucuc ggaagcugca gccaugaugg aaguuugaga guugagccgc      240

ugugaggcga ggccgggcuc aggcgaggga gaugagagac ggcggcggcc gcggcccgga      300

gccccucuca gcgccuguga gcagccgcgg gggcagcgcc cucggggagc cggccggccu      360

gcggcggcgg cagcggcggc guuucucgcc uccucuucgu cuuuucuaac cgugcagccu      420

cuuccucggc uucuccugaa agggaaggug gaagccgugg gcucgggcgg gagccggcug      480

aggcgcggcg gcggcggcgg caccucccgc ucauggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggcugca gcuccaggga gggggucuga gucgccuguc accauuucca      600

gggcugggaa cgccggagag uuggucucuc cccuucuacu gccuccaaca cggcggcggc      660

ggcggcggca cauccaggga cccgggccgg uuuuaaaccu cccguccgcc gccgccgcac      720

cccccguggc ccgggcuccg gaggccgccg gcggaggcag ccguucggag gauuauucgu      780

cuucucccca uuccgcugcc gccgcugcca ggccucuggc ugcugaggag aagcaggccc      840

agucgcugca accauccagc agccgccgca gcagccauua cccggcugcg guccagagcc      900

aagcggcggc agagcgaggg gcaucagcua ccgccaaguc cagagccauu uccauccugc      960

agaagaagcc ccgccaccag cagcuucugc caucucucuc cuccuuuuuc uucagccaca     1020

ggcucccaga caugacagcc aucaucaaag agaucguuag cagaaacaaa aggagauauc     1080

aagaggaugg auucgacuua gacuugaccu auauuuaucc aaacauuauu gcuaugggau     1140

uuccugcaga aagacuugaa ggcguauaca ggaacaauau ugaugaugua guaagguuuu     1200

uggauucaaa gcauaaaaac cauuacaaga uauacaaucu uugugcugaa agacauuaug     1260

acaccgccaa auuuaauugc agaguugcac aauauccuuu ugaagaccau aacccaccac     1320

agcuagaacu uaucaaaccc uuuugugaag aucuugacca auggcuaagu gaagaugaca     1380

aucauguugc agcaauucac uguaaagcug gaaagggacg aacuggugua augauaugug     1440

cauauuuauu acaucggggc aaauuuuuaa aggcacaaga ggcccuagau uucuaugggg     1500

aaguaaggac cagagacaaa aagggaguaa cuauucccag ucagaggcgc uauguguauu     1560

auuauagcua ccuguuaaag aaucaucugg auuauagacc aguggcacug uuguuucaca     1620

agaugauguu ugaaacuauu ccaauguuca guggcggaac uugcaauccu caguuugugg     1680

ucugccagcu aaaggugaag auauauuccu ccaauucagg acccacacga cgggaagaca     1740

aguucaugua cuuugaguuc ccucagccgu uaccugugug uggugauauc aaaguagagu     1800

ucuuccacaa acagaacaag augcuaaaaa aggacaaaau guuucacuuu uggguaaaua     1860

cauucuucau accaggacca gaggaaaccu cagaaaaagu agaaaaugga agucuaugug     1920

aucaagaaau cgauagcauu ugcaguauag agcgugcaga uaaugacaag gaauaucuag     1980

uacuuacuuu aacaaaaaau gaucuugaca aagcaaauaa agacaaagcc aaccgauacu     2040

uuucuccaaa uuuuaaggug aagcuguacu ucacaaaaac aguagaggag ccgucaaauc     2100

cagaggcuag caguucaacu ucuguaacac cagauguuag ugacaaugaa ccugaucauu     2160

auagauauuc ugacaccacu gacucugauc cagagaauga accuuuugau gaagaucagc     2220

auacacaaau uacaaaaguc ugaauuuuuu uuuaucaaga gggauaaaac accaugaaaa     2280

uaaacuugaa uaaacugaaa auggaccuuu uuuuuuuuaa uggcaauagg acauuguguc     2340

agauuaccag uuauaggaac aauucucuuu uccugaccaa ucuuguuuua cccuauacau     2400

ccacaggguu uugacacuug uuguccaguu gaaaaaaggu uguguagcug ugucauguau     2460

auaccuuuuu gugucaaaag gacauuuaaa auucaauuag gauuaauaaa gauggcacuu     2520

ucccguuuua uuccaguuuu auaaaaagug gagacagacu gauguguaua cguaggaauu     2580

uuuuccuuuu guguucuguc accaacugaa guggcuaaag agcuuuguga uauacugguu     2640

cacauccuac cccuuugcac uuguggcaac agauaaguuu gcaguuggcu aagagagguu     2700

uccgaagggu uuugcuacau ucuaaugcau guauucgggu uaggggaaug gagggaaugc     2760

ucagaaagga aauaauuuua ugcuggacuc uggaccauau accaucucca gcuauuuaca     2820

cacaccuuuc uuuagcaugc uacaguuauu aaucuggaca uucgaggaau uggccgcugu     2880

cacugcuugu uguuugcgca uuuuuuuuua aagcauauug gugcuagaaa aggcagcuaa     2940

aggaagugaa ucuguauugg gguacaggaa ugaaccuucu gcaacaucuu aagauccaca     3000

aaugaaggga uauaaaaaua augucauagg uaagaaacac agcaacaaug acuuaaccau     3060

auaaaugugg aggcuaucaa caaagaaugg gcuugaaaca uuauaaaaau ugacaaugau     3120

uuauuaaaua uguuuucuca auuguaacga cuucuccauc uccuguguaa ucaaggccag     3180

ugcuaaaauu cagaugcugu uaguaccuac aucagucaac aacuuacacu uauuuuacua     3240

guuuucaauc auaauaccug cuguggaugc uucaugugcu gccugcaagc uucuuuuuuc     3300

ucauuaaaua uaaaauauuu uguaaugcug cacagaaauu uucaauuuga gauucuacag     3360

uaagcguuuu uuuucuuuga agauuuauga ugcacuuauu caauagcugu cagccguucc     3420

acccuuuuga ccuuacacau ucuauuacaa ugaauuuugc aguuuugcac auuuuuuaaa     3480

ugucauuaac uguuagggaa uuuuacuuga auacugaaua cauauaaugu uuauauuaaa     3540

aaggacauuu guguuaaaaa ggaaauuaga guugcaguaa acuuucaaug cugcacacaa     3600

aaaaaagaca uuugauuuuu caguagaaau uguccuacau gugcuuuauu gauuugcuau     3660

ugaaagaaua ggguuuuuuu uuuuuuuuuu uuuuuuuuuu uuaaaugugc aguguugaau     3720

cauuucuuca uagugcuccc ccgaguuggg acuagggcuu caauuucacu ucuuaaaaaa     3780

aaucaucaua uauuugauau gcccagacug cauacgauuu uaagcggagu acaacuacua     3840

uuguaaagcu aaugugaaga uauuauuaaa aagguuuuuu uuuccagaaa uuuggugucu     3900

ucaaauuaua ccuucaccuu gacauuugaa uauccagcca uuuuguuucu uaaugguaua     3960

aaauuccauu uucaauaacu uauuggugcu gaaauuguuc acuagcugug gucugaccua     4020

guuaauuuac aaauacagau ugaauaggac cuacuagagc agcauuuaua gaguuugaug     4080

gcaaauagau uaggcagaac uucaucuaaa auauucuuag uaaauaaugu ugacacguuu     4140

uccauaccuu gucaguuuca uucaacaauu uuuaaauuuu uaacaaagcu cuuaggauuu     4200

acacauuuau auuuaaacau ugauauauag aguauugauu gauugcucau aaguuaaauu     4260

gguaaaguua gagacaacua uucuaacacc ucaccauuga aauuuauaug ccaccuuguc     4320

uuucauaaaa gcugaaaauu guuaccuaaa augaaaauca acuucauguu uugaagauag     4380

uuauaaauau uguucuuugu uacaauuucg ggcaccgcau auuaaaacgu aacuuuauug     4440

uuccaauaug uaacauggag ggccagguca uaaauaauga cauuauaaug ggcuuuugca     4500

cuguuauuau uuuuccuuug gaaugugaag gucugaauga ggguuuugau uuugaauguu     4560

ucaauguuuu ugagaagccu ugcuuacauu uuauggugua gucauuggaa auggaaaaau     4620

ggcauuauau auauuauaua uauaaauaua uauuauacau acucuccuua cuuuauuuca     4680

guuaccaucc ccauagaauu ugacaagaau ugcuaugacu gaaagguuuu cgaguccuaa     4740

uuaaaacuuu auuuauggca guauucauaa uuagccugaa augcauucug uagguaaucu     4800

cugaguuucu ggaauauuuu cuuagacuuu uuggaugugc agcagcuuac augucugaag     4860

uuacuugaag gcaucacuuu uaagaaagcu uacaguuggg cccuguacca ucccaagucc     4920

uuuguagcuc cucuugaaca uguuugccau acuuuuaaaa ggguaguuga auaaauagca     4980

ucaccauucu uugcuguggc acagguuaua aacuuaagug gaguuuaccg gcagcaucaa     5040

auguuucagc uuuaaaaaau aaaaguaggg uacaaguuua auguuuaguu cuagaaauuu     5100

ugugcaauau guucauaacg auggcugugg uugccacaaa gugccucguu uaccuuuaaa     5160

uacuguuaau gugucaugca ugcagaugga agggguggaa cugugcacua aagugggggc     5220

uuuaacugua guauuuggca gaguugccuu cuaccugcca guucaaaagu ucaaccuguu     5280

uucauauaga auauauauac uaaaaaauuu cagucuguua aacagccuua cucugauuca     5340

gccucuucag auacucuugu gcugugcagc aguggcucug uguguaaaug cuaugcacug     5400

aggauacaca aaaauaccaa uaugaugugu acaggauaau gccucauccc aaucagaugu     5460

ccauuuguua uuguguuugu uaacaacccu uuaucucuua guguuauaaa cuccacuuaa     5520

aacugauuaa agucucauuc uugucaaaaa aaaaaaaaaa aaaaaaaaaa aa             5572


<210>  7
<211>  5572
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (513)..(515)
<223>  Engineered AUG initiation codon of PTEN-long analogue

<400>  7
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcatggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aa             5572